Protein Details: Amiloride-sensitive sodium channel subunit alpha
Protein ID
ICDB_Pro_0165
Protein Name
Amiloride-sensitive sodium channel subunit alpha
Gene Name
SCNN1A
Organism
Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis)
Length
642 amino acids
AlphaFoldDB
AF-K7GET2-F1-model_v4.pdb
Function
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water; which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis; but also in airway surface liquid homeostasis; which is important for proper clearance of mucus.
Sequence
MHQVVTVKAEKVPMGKRLRRCKQEAENQQKVEEVAEKLEKEHEGLIEFHKSYHELFQFFCNNTTIHGAIRLVCSKRNKMKTAFWSVLFFLTFGLMYWQFGILYREYFSFPVNLNLNLNSDKLTFPAVTLCTLNPYRYSAVRKELDELDRITHQTLMDLYNYSMSQVQSNGAAQSSQKRSQRSLSHHVQRHPLRRRKRNEPVSLKGNSPPVDKSDWKIGFILCNETNEDCFHQTYSSGVDAVREWYSFHYINILARMPDTKALDESNFESFIYACRFNEVTCDKANYTHFHHPLYGNCYTFNDRNNSLWTSSLPGINNGLSLLVRTEQNDYIPLLSTVTGARVMVHEQNEPAFMDDGGFNVRPGIETSISMRKETTMLLGGSYSDCTEDGSDVPVQNLYSSRYTEQVCIRSCFQIHMVKRCGCAYYFYPLPPGAEYCDYTKHIAWGYCYYKLQVEFKSNILGCFSKCRKPCEVTKYQLSAGYSHWPSAVSENWVFHILSQQNKYNITSKRNGVAKVNIFFEEWKYKTNGESPAFTVVTLLSQLGNQWSLWFGSSVLSVVELAELILDFIAITIILSFKRFRSRQVPAPSVPPPGAHDNTAFQSEPADPSAPHRFTVEAVVTTLPSYNSLEPCRRDGEAVIGLE
PDB Structures
Ligand Binding
Binding Site
Disease
Location
DOI ID
RefSeq
XP_006124236.1